In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart Valves
نویسندگان
چکیده
منابع مشابه
Tissue-engineered heart valves.
Currently-used mechanical and biological heart valve prostheses have several disadvantages. Mechanical prostheses, based on carbon, metallic and polymeric components, require permanent anticoagulation treatment, and their usage often leads to adverse reactions, e.g. thromboembolic complications and endocarditis. Xenogenous and allogenous biological prostheses are associated with immune reaction...
متن کاملCurrent Challenges in Translating Tissue-Engineered Heart Valves
OPINION STATEMENT Heart valve disease is a major health burden, treated by either valve repair or valve replacement, depending on the affected valve. Nearly 300,000 valve replacements are performed worldwide per year. Valve replacement is lifesaving, but not without complications. The in situ tissue-engineered heart valve is a promising alternative to current treatments, but the translation of ...
متن کاملEarly in vivo experience with tissue-engineered trileaflet heart valves.
BACKGROUND Tissue engineering is a new approach in which techniques are being developed to transplant autologous cells onto biodegradable scaffolds to ultimately form new functional autologous tissue. Workers at our laboratory have focused on tissue engineering of heart valves. The present study was designed to evaluate the implantation of a whole trileaflet tissue-engineered heart valve in the...
متن کاملClinical results of implanted tissue engineered heart valves
Since the first heterotopic implantation of a biological heart valve in 1955 by Murray, bioprostheses have been steadily improved. For allografts different methods have been evaluated and modified to stabilize and preserve the available tissue. Xenografts were fixed to cross-link the connective tissue as well as prevent immunogenic reactions. Nevertheless, gluteraldehyde fixation leads to struc...
متن کاملTissue engineered heart valves: will a clinical application be possible?
Artificial valves have been used as the ultimate treatment for cardiac valvular diseases with severe morphologic and functional disorders. Currently, artificial cardiac valves are the most widely used artificial organ, but there remain problems, such as materials, opening and closing mechanisms, and distal control. The best artificial organs are considered to function in the same manner as the ...
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ژورنال
عنوان ژورنال: JACC: Basic to Translational Science
سال: 2020
ISSN: 2452-302X
DOI: 10.1016/j.jacbts.2020.09.011